| Annotated protein: | Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2). Gene symbol: DLGAP2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BJ42 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DLGAP2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Schutt J, et al. "Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities" J Biol Chem. 2009 Sep 18;284(38):25479-87 PMID:19640847 |
| Figure(s): | Figure 1 C and E |
| Annotation description: | Figure1, DLGAP2/SAPAP2 is enriched in the PSD fraction. "For the comparative analysis of PSD fractions, equal protein amounts were analyzed by Western blotting with specific antibodies (Fig. 1, C and E). In contrast, SAPAP1 and Shank3 levels were only elevated in neocortical PSD preparations, whereas SAPAP2, SAPAP3, and IRSp53 concentrations were selectively increased in hippocampal PSD fractions prepared from knockout animals. 28/01/2021 Dnyanada: The paper does not comment on the specificity of the antibody used. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 4210 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |