| Annotated protein: | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (PTPNU-3) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma). Gene symbol: PTPRS. Taxonomy: Mus musculus (Mouse). Uniprot ID: B0V2N1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRS |
| Ontology domain: | Biological Process |
| SynGO term: | trans-synaptic signaling (GO:0099537) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Kim K, et al. "Presynaptic PTPsigma regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms" Elife. 2020 Mar 6;9:e54224 PMID:32142410 |
| Figure(s): | Figure 1E,F,I, Figure 2, and Figure 3 |
| Annotation description: | This paper shows that PTPRS deletion in excitatory neurons in the cortex and hippocampus by conditional KO approach leads to decreased NMDAR currents and NMDAR-dependent LTP in the postsynaptic side of excitatory synapses at hippocampal CA3-CA1 synapses, suggestive of trans-synaptic regulation of postsynaptic NMDAR function by a presynaptic adhesion molecule, although it does not seem to involve a direct transsynaptic interaction of PTPRS with its knwon postsynaptic adhesion partners such as HSPG/CSPG or Slitrk1/TrkC. Another supportive paper from Thomas Sudhof's group (see above) demonstrates that a triple deletion of PTPRS, PTPRD, and LAR (three known members of the LAR family of receptor tyrosine phosphatases) leads to decreased postsynaptic NMDAR currents, again supportive of transsynaptic mechanisms. Descriptions in Figure legends. Figure 1. Normal spontaneous and evoked basal synaptic transmission but suppressed NMDAR-dependent synaptic transmission and plasticity in the Emx1-Cre;Ptprsfl/fl hippocampus. (E) Suppressed HFS-LTP at Emx1-Cre;Ptprsfl/fl SC-CA1 synapses (P26-32). (F) Suppressed TBS-LTP at Emx1-Cre;Ptprsfl/fl SC-CA1 synapses (P26-32). Figure 2. Deletion of presynaptic, but not postsynaptic, PTPσ suppresses TBS-LTP at SC-CA1 synapses. Figure 3. Re-expression of presynaptic PTP σ rescues postsynaptic LTP in the hippocampus through mechanisms independent of the extracellular region of PTPσ. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Field recordings |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | Title: LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses. -->Triple deletion of LAR family protein tyrosine phosphatases (PTPs, PTPd, and LAR) leads to decreased NMDAR currents. @ PMID:31985401 |
| SynGO annotation ID: | 4203 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |