| Annotated protein: | BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B). Gene symbol: NTRK2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63604 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NTRK2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic membrane (GO:0045211) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Aoki C, et al. "Localization of brain-derived neurotrophic factor and TrkB receptors to postsynaptic densities of adult rat cerebral cortex" J Neurosci Res. 2000 Feb 1;59(3):454-63 PMID:10679783 |
| Figure(s): | Figure 5 |
| Annotation description: | Description in Figure 5 legend. Fig. 5. "Electron micrographs showing trkB immunoreactivity over postsynaptic densities(PSDs). Anti-trkBout antisera were used. In (A) and other pan-els, curved arrows point to immunoreactive postsynaptic densities(PSDs) and open arrows point to unlabeled PSDs and arrowheads point to symmetric synaptic junctions. " - "Peroxidase reaction product accumulated over PSDs of spines (Figs. 5A-D)." 19/01/2021 Dnyanada: Figure 4: Western blot analysis using anti-trkBin reveals the full-length trkB and several minor bands in the PSD (Fig. 4A). The bands were abolished using antibodies preadsorbed with the peptide antigens (Fig.4B), indicating specificity of the immunoreaction. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 4195 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |