| Annotated protein: | Brain-enriched guanylate kinase-associated protein. Gene symbol: BEGAIN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O88881 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ BEGAIN |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | brain, glutamatergic hippocampus, glutamatergic |
| Annotated paper: | Deguchi M, et al. "BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein" J Biol Chem. 1998 Oct 9;273(41):26269-72 PMID:9756850 |
| Figure(s): | Fig. 3, Y2H screen not shown in figure. |
| Annotation description: | Fig. 3: coimmunoprecipitation with PSD-95 and SAPAP, colocalization with PSD-95 in rat hippocampal neurons. Note: BEGAIN was cloned by Yeast Two-hybrid Screening using the SH3 and GK domains of PSD-95 as bait. 13/4/2017 Pim - hotspots of PSD-95 are interpreted as synapses for this annotation. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence IP + WB/MSMS Y2H |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 417 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |