| Annotated protein: | Cytohesin-2 (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) (CLM2) (SEC7 homolog B) (mSec7-2). Gene symbol: CYTH2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63034 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CYTH2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Ito A, et al. "Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons" J Neurochem. 2018 Oct;147(2):153-177 PMID:30151872 |
| Figure(s): | Fig1 |
| Annotation description: | Fig1 shows the localization of cytohesin-2 (ARNO) in mouse hippocampus CA1 region. Panel P shows immunogold localization to spines (PSD is visible, indicating glutamate synapse) by EM, and the immunogold reactivity for cytohesin-2 is quantified in panel Q, showing the highest density in spines. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4169 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |