| Annotated protein: | Mu-type opioid receptor (M-OR-1) (MOR-1). Gene symbol: OPRM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P42866 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ OPRM1 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Shao C, et al. "Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells" Biochem Biophys Res Commun. 2020 Feb 19;522(4):1059-1062 PMID:31818459 |
| Figure(s): | Figure 1 |
| Annotation description: | It is known that activation of opioid receptors leads to the activation of inwardly rectifying potassium channels and inhibition of voltage-gated calcium channels, leading to a decrease in neurotransmitter release (reviewed in PMID: 30301203). Figure 1. In this work the authors show that Parvalbumin expressing (PV) neurons release GABA onto pyramidal cells, and this process is modulated by presynaptic μ opioid receptors (MORs). Activating PV cells using optogenetics, the authors identify GABAergic postsynaptic currents (dissected using pharmacology) and show that pharmacological activation of MORs (using DAMGO) leads to a decrease in GABA release into pyramidal cells (Figure 1B). This activation can be blocked by naloxone pretreatment (an MOR antagonist) to show the specificity of MOR activation (Figure 1C). As it is known that MORs depress presynaptic release by modulating voltage-gated calcium channels, MOR is annotated for "presynaptic modulation of chemical synaptic transmission". |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Optical physiology |
| Annotator(s): | Carlos Pascual-Caro (ORCID:0000-0002-2345-393X) Anjali Amrapali Vishwanath (ORCID:0000-0002-9888-0928) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) |
| Lab: | ICM - Brain and Spine Institute, Hpital Piti Salptrire, 47 Boulevard de l'Hpital, 75013 Paris, France |
| Additional literature: | This review discusses how activation of opioid receptors leads to the activation of inwardly rectifying potassium channels and inhibition of voltage-gated calcium channels, leading to a decrease in neurotransmitter release. @ PMID:30301203 |
| SynGO annotation ID: | 4157 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |