| Annotated protein: | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (CD antigen CD71). Gene symbol: TFRC. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q62351 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TFRC |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Liu K, et al. "Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity" Sci Rep. 2016 Feb 16;6:21019 PMID:26880306 |
| Figure(s): | Fig1 |
| Annotation description: | Fig S1B: Subcellular distribution pattern of TFR was similar to other synaptic proteins suggesting synaptic location. Fig1A-D: Immunofluorescence staining in hippocampal neurons showed that TFR largely co-localized with the postsynaptic marker PSD95 but rarely with pre-synaptic protein synaptophysin and partially co-localized with AMPA receptor subunits GluR1 and GluR2. Fig1E: Quantification of the colocalisation index shows higher colocalisation of TFR with postsynaptic marker PSD95 compared to presynaptic marker synaptophysin. Fig1G: TFR KO hippocampal neurons demonstrate an ablation of the anti-TFR signal indicating specificity of the antibody. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Dnyanada Sahasrabudhe (ORCID:0000-0003-2916-7616) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4116 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |