Annotated protein:RalA-binding protein 1 (RalBP1) (Cytocentrin) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1). Gene symbol: RALBP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62796
antibody wiki:
SynGO gene info:SynGO data @ RALBP1
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)
Synapse type(s):hippocampus
Schaffer collateral synapse (CA3->CA1)
Annotated paper:Han K, et al. "Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD" PLoS Biol. 2009 Sep;7(9):e1000187 PMID:19823667
Figure(s):Figs 4, 6, 8, 9, 10, 11, S7
Annotation description:Activation of NMDAR causes activation of RalA which in turn binds and translocates RalBP1 to dendritic spines. This causes endocytosis of the GluR2 subunit of the AMPAR complex and subsequent LTD state.

RalBP1-/- mice show impaired NMDAR-dependent LTD at CA1 synapses.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
RNAi / shRNA
Over-expression
Antagonist / agonist
Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Whole-cell patch clamp
IP + WB/MSMS
Annotator(s):John Chua (ORCID:0000-0002-5615-1014)
Lab:Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore
SynGO annotation ID:4087
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology