| Annotated protein: | Somatostatin (somatotropin release-inhibiting factor) (SRIF) [Cleaved into: Antrin; Somatostatin-28; Somatostatin-14; Neuronostatin (NST)]. Gene symbol: SST. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P60042 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SST |
| Ontology domain: | Cellular Component |
| SynGO term: | neuronal dense core vesicle (GO:0098992) |
| Synapse type(s): | hypothalamus |
| Annotated paper: | van den Pol AN, et al. "Gamma-aminobutyrate, gastrin releasing peptide, serotonin, somatostatin, and vasopressin: ultrastructural immunocytochemical localization in presynaptic axons in the suprachiasmatic nucleus" Neuroscience. 1986 Mar;17(3):643-59 PMID:2422591 |
| Figure(s): | Figure 6 |
| Annotation description: | Figure 6: Immunoelectron microscopy localises the SST immunoreaction product on dense-core vesicles (marked by small arrowhead). The synaptic membrane is marked by large arrows. The paper mentions that the antibody against SST was from M. Sofroniew. Immunonuclear Corporation. It mentions that antibody specificity tests were described in PMID: 2413388, however, the paper fails to show any data on it. Given that the paper was published in 1986, it is difficult to find any additional information. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Dnyanada Sahasrabudhe (ORCID:0000-0003-2916-7616) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 4078 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |