| Annotated protein: | Ras-related protein Ral-A (EC 3.6.5.2). Gene symbol: RALA. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P63322 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RALA |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Han K, et al. "Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD" PLoS Biol. 2009 Sep;7(9):e1000187 PMID:19823667 |
| Figure(s): | Figs 4, 6, 7, 8, 10, 11, S7, S8 and S9 |
| Annotation description: | Activation of NMDAR causes activation of RalA which in turn binds and translocates RalBP1 to dendritic spines. This causes endocytosis of the GluR2 subunit of the AMPAR complex and subsequent LTD state. Additionally, RalA itself is involved in maintaining basal levels of AMPAR by inhibiting basal AMPAR endocytosis in a GTP-independent manner. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Over-expression Antagonist / agonist Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| SynGO annotation ID: | 3990 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |