| Annotated protein: | Prohibitin 1. Gene symbol: PHB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P67779 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PHB1 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Smalla KH, et al. "A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia" Mol Psychiatry. 2008 Sep;13(9):878-96 PMID:18504422 |
| Figure(s): | Fige. 3, 5 e-g |
| Annotation description: | Prohibitin immunoreactivity colocalizes with presynaptic (Bassoon) and postsynaptic (Shank 3) marker proteins in cortical primary cultures. 12/01/2021 Dnyanada: The additional literature (PMID: 23622064) identifies prohibitin in presynaptic active zone fraction. The confocal images used in the annotated paper do not have the resolution to discriminate between pre- and postsynaptic localisation. Due to a lack of strong experimental evidence in favour of either the presynapse or postsynapse, the SynGO term "synapse" was used. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Proteomic study of the presynaptic active zone, Suppl. S1, S5. Prohibitin (as well as Prohibitin-2) has no detectable transmembrane domain, however, it copurifies with protein fractions highly enriched in docked synaptic vesicles. @ PMID:23622064 |
| SynGO annotation ID: | 3986 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |