| Annotated protein: | Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha). Gene symbol: RABEP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35550 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RABEP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic cytosol (GO:0099523) |
| Synapse type(s): | forebrain |
| Annotated paper: | Neve RL, et al. "The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis" J Neurosci. 1998 Oct 1;18(19):7757-67 PMID:9742146 |
| Figure(s): | Figs 2 and 3 |
| Annotation description: | Using subcellular fraction and immunbloting, Rabaptin-5 is detected in synaptosomal fractions. This was partially validated by the detection of the protein with synaptic vesicle clusters in primary cortical cultures using immuno-electron microscopy. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Western blot Biochemical fractionation (generic) |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| SynGO annotation ID: | 3979 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |