| Annotated protein: | Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1 homolog). Gene symbol: FLOT2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q60634 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FLOT2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Bodrikov V, et al. "Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons" Exp Neurol. 2017 Mar;289:31-45 PMID:27993509 |
| Figure(s): | Fig. 4 |
| Annotation description: | Flotillin-2 regulates in cooperation with Rab11a membrane trafficking processes in spines and participates in LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons. 13/4/2017 Pim Fig.4 - shRNA KD of Reggie1 or reggie2 results in reduction of surface AMPAR clusters in a protocol of chemical LTP. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | NMDA receptors interact with flotillin-1 and -2 @ PMID:19298817 |
| SynGO annotation ID: | 397 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |