| Annotated protein: | Syntaxin-12 (Syntaxin-13). Gene symbol: STX12. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: G3V7P1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STX12 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Park M, et al. "Recycling endosomes supply AMPA receptors for LTP" Science. 2004 Sep 24;305(5692):1972-5 PMID:15448273 |
| Figure(s): | Fig2A, B and E, Fig3B |
| Annotation description: | Fig2 shows cells expressing syntaxin13 (STX13) lacking its transmembrane domain AMPA receptors are no longer inserted upon stimulation. Fig 3 shows that LTP is blocked by the acute infusion of STX13-dTM peptide, and not by another syntaxin molecule (STX7), suggesting the effect is specific to STX13. Given that STX13 is localised at recycling endosomes (see CC ticket), it is unlikely that STX13 is directly involved in the delivery of AMPA receptors to the plasma membrane, rather is regulates this process. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3963 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |