| Annotated protein: | Syntaxin-12 (Syntaxin-13). Gene symbol: STX12. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: G3V7P1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STX12 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic recycling endosome membrane (GO:0099063) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Park M, et al. "Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes" Neuron. 2006 Dec 7;52(5):817-30 PMID:17145503 |
| Figure(s): | Figure 1 |
| Annotation description: | Fig 1 shows the quantification and examples of transferrin-labelled syntaxin13 positive structures (to disambiguate: the streetname is syntaxin13, whereas the gene symbol is STX12). 50% of these structures are localised to the spine head (Fig 1C). Evidence from Tf uptake in this experiment and extensive characterisation in heterologous cells and neurons (see supporting refs) indicates these are tubular recycling endosomes. Based on the known transmembrane topology of this protein, "integral component of ... membrane" term was selected. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | This study shows in hetrologous cells that syntaxin13 is localized to transferin-positive tubular endosomes. The most direct evidene is in Fig 7, where double-immuno-gold EM is used, showing Syn13 and Tf on tubular recycling endosomal elements. @ PMID:9817754 Fig 4 shows immuno-gold colocalization of syntaxin13 and endosome marker Rab4 on tubular endosomes in hippocampal neurons. @ PMID:20098723 |
| SynGO annotation ID: | 3962 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |