| Annotated protein: | Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1). Gene symbol: SLC1A1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P51906 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC1A1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Scimemi A, et al. "Neuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampus" J Neurosci. 2009 Nov 18;29(46):14581-95 PMID:19923291 |
| Figure(s): | Fig 6 |
| Annotation description: | Fig 6A shows that theta burst stimulation induces LTP in the Schaffer collateral pathway (Test) not in the control pathway (ctrl). The LTP is absent in the EAAC1 knockout mouse (Fig 6C, D), and can be restored by Ifenprodil (Fig 6E, F), an NR2B-NMDA receptor antagonist. This indicates that EAAC1 limits NR2B NMDA receptor activation (see Fig 5), and modulation of this activation is affecting TBS LTP. Incubating the WT slice in DHK, a specific GLT-1 blocker, did not affect LTP, showing that this effect is specific for EAAC1 transporters and not extended to other glutamate transporters. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3959 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |