| Annotated protein: | Amino acid transporter. Gene symbol: SLC1A1. Taxonomy: Macaca fascicularis (Crab-eating macaque). Uniprot ID: A0A2K5WLA0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC1A1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Annotated paper: | He Y, et al. "Differential synaptic localization of GluR2 and EAAC1 in the macaque monkey entorhinal cortex: a postembedding immunogold study" Neurosci Lett. 2001 Oct 5;311(3):161-4 PMID:11578819 |
| Figure(s): | Fig 1 and 2 |
| Annotation description: | Quantitative immuno-gold EM in macaque monkey enthorynal cortex show that EAAC1 is present predominantly at the edge of the PSD (peri-PSD) in the spine plasma membrane. These data are replicated in rodent hippocampus tissue (see supporting refs). No significant immuno-reactivity is observed in the presynaptic terminal. As EAAC1 is a transporter with several transmembrane regions (see UniProt F7H624 (F7H624_MACMU)), the localisation is integral to the spine membrane. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Fig 4-7 show similar peri-PSD distribution of EAAC1 in spines of rat CA1 hippocampus tissue. Examples in Fig 4 and 5, quantification in fig 6 and 7. @ PMID:10701825 Fig 13 shows similar distribution of EAAc1 in dentate gyrus of mouse hippocampus (just typical examples, no quantification) @ PMID:22539860 |
| SynGO annotation ID: | 3957 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |