Annotated protein: | cAMP-dependent protein kinase type I-beta regulatory subunit. Gene symbol: PRKAR1B. Taxonomy: Mus musculus (Mouse). Uniprot ID: P12849 |
antibody wiki: | |
SynGO gene info: | SynGO data @ PRKAR1B |
Ontology domain: | Cellular Component |
SynGO term: | postsynapse (GO:0098794) |
Synapse type(s): | hippocampus, glutamatergic |
Annotated paper: | Zhong H, et al. "Subcellular dynamics of type II PKA in neurons" Neuron. 2009 May 14;62(3):363-74 PMID:19447092 |
Figure(s): | Figure 1, 2 |
Annotation description: | Zhong et.al. use overexpression of GFP-tagged proteins to test the subcellular localization of PKA subunits in hippocampal slice cultures. They observe that PKA R1b-GFP is present in dendrites, including dendritic spines (Figure 2C, D). It is also observed that PKA R1b-GFP expression is somewhat reduced in the axon. This indicates that this experiment has at least some specificity, but the evidence is not very strong. |
Evidence tracking, Biological System: | Intact tissue |
Evidence tracking, Protein Targeting: | Over-expression |
Evidence tracking, Experiment Assay: | Two-photon microscopy |
Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
SynGO annotation ID: | 3955 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |