| Annotated protein: | cAMP-dependent protein kinase type II-beta regulatory subunit. Gene symbol: PRKAR2B. Taxonomy: Mus musculus (Mouse). Uniprot ID: P31324 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRKAR2B |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zhong H, et al. "Subcellular dynamics of type II PKA in neurons" Neuron. 2009 May 14;62(3):363-74 PMID:19447092 |
| Figure(s): | Figure 1, 2 |
| Annotation description: | Zhong et.al. use overexpression of GFP-tagged proteins to test the subcellular localization of PKA subunits in hippocampal slice cultures. They observe that PKA R1a-GFP is present in dendrites, including dendritic spines (Figure 2C, D). It is also observed that PKA R1a-GFP expression is somewhat reduced in the axon. This indicates that this experiment has at least some specificity, but the evidence is not very strong. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Two-photon microscopy |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| SynGO annotation ID: | 3954 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |