| Annotated protein: | Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8). Gene symbol: EXOC4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62824 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EXOC4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Sans N, et al. "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex" Nat Cell Biol. 2003 Jun;5(6):520-30 PMID:12738960 |
| Figure(s): | Figs 2&3 |
| Annotation description: | Exoc4/Sec8 interacts with PDZ domain of SAP102 forming a complex with NMDARs. Double-labelling with SAP102 and Sec6-Sec8 showed colocalization associated with rough endoplasmic reticulum and other organelles in the soma, as well as with vesicles and presumptive tubulovesicular structures throughout the soma, neurites, growth cones, early synaptic contacts and post-synaptic densities. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3945 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |