| Annotated protein: | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA). Gene symbol: RPS6KB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P67999 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPS6KB1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Cammalleri M, et al. "Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1" Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14368-73 PMID:14623952 |
| Figure(s): | fig 5c and 5d |
| Annotation description: | In dendrites (c and d), Thr-389-P p70S6K was present in a subset of dendritic spines as revealed by double labeling for actin filaments. The authors speculate the morphology of Thr-389-P p70S6K-immunoreactive puncta in dendritic shafts was similar to the morphology of hotspots of dendritic translation demonstrated in other papers in similarly cultured primary hippocampal neurons. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 3922 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |