| Annotated protein: | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RLSK). Gene symbol: RPS6KA5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8C050 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPS6KA5 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Karelina K, et al. "MSK1 regulates environmental enrichment-induced hippocampal plasticity and cognitive enhancement" Learn Mem. 2012 Oct 17;19(11):550-60 PMID:23077336 |
| Figure(s): | Fig.2b |
| Annotation description: | Dendritic spine density is increased in enriched WT mice compared to enriched MSK1-/- mice in all three hippocampal regions; GCL, CA1 and CA3 |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Microscopy (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 3920 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |