| Annotated protein: | Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein). Gene symbol: SNAP25. Taxonomy: Mus musculus (Mouse). Uniprot ID: P60879 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SNAP25 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle exocytosis (GO:0016079) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Delgado-Martinez I, et al. "Differential abilities of SNAP-25 homologs to support neuronal function" J Neurosci. 2007 Aug 29;27(35):9380-91 PMID:17728451 |
| Figure(s): | Fig 4 |
| Annotation description: | deletion of SNAP-25 leads to strongly reduced neuron survival, and, in the few surviving cells, impaired arborization, reduced spontaneous release, and complete arrest of evoked release. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 39 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |