| Annotated protein: | Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2). Gene symbol: LPAR1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P61794 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LPAR1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle cycle (GO:0098693) |
| Synapse type(s): | medulla, glutamatergic |
| Annotated paper: | Garcia-Morales V, et al. "Membrane-derived phospholipids control synaptic neurotransmission and plasticity" PLoS Biol. 2015 May 21;13(5):e1002153 PMID:25996636 |
| Figure(s): | Fig.3, 4, 5 |
| Annotation description: | Fig.3: "Presynaptic LPA signaling induces excitatory STD" Fig.4: "LPA modulates AMPAR-mediated neurotransmission via LPA1/Gαi/o-PLC" Fig.5: "LPA rearranges SVs at excitatory boutons in a MLCK-dependent manner." 9/7/2018 Pim: The authors show that LPA modulates the presynaptic RRP of glutamatergic SVs, that LPA1 is located in the presynaptic compartment, and that KD of LPA1 to a large extent supresses the LPA effect on glutamatergic SVs. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Western blot |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3866 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |