| Annotated protein: | Integrin alpha-3 (CD49 antigen-like family member C) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]. Gene symbol: ITGA3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q62470 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ITGA3 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse organization (GO:0099173) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Omar MH, et al. "CNS Neurons Deposit Laminin alpha5 to Stabilize Synapses" Cell Rep. 2017 Oct 31;21(5):1281-1292 PMID:29091766 |
| Figure(s): | Fig.5 |
| Annotation description: | [Fig.2: "Laminin α5 Attenuates Dendritic Spine Structural Dynamics and Regulates Spine Head Size"] [Fig.3: "Loss of Laminin α5 from Excitatory Neurons Disrupts Hippocampal Synapses and Animal Behavior"] Fig.5: "Laminin α5 Interacts Functionally with Integrin α3 to Regulate Spine Density and Animal Behavior" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3863 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |