| Annotated protein: | Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha). Gene symbol: LAMA5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61001 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LAMA5 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse organization (GO:0099173) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Omar MH, et al. "CNS Neurons Deposit Laminin alpha5 to Stabilize Synapses" Cell Rep. 2017 Oct 31;21(5):1281-1292 PMID:29091766 |
| Figure(s): | Fig.2, 3, 5 |
| Annotation description: | Fig.2: "Laminin α5 Attenuates Dendritic Spine Structural Dynamics and Regulates Spine Head Size" Fig.3: "Loss of Laminin α5 from Excitatory Neurons Disrupts Hippocampal Synapses and Animal Behavior" Fig.5: "Laminin α5 Interacts Functionally with Integrin α3 to Regulate Spine Density and Animal Behavior" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3862 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |