| Annotated protein: | Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2). Gene symbol: NETO2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: C6K2K4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NETO2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Sheng N, et al. "Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1" Elife. 2015 Dec 31;4:e11682 PMID:26720915 |
| Figure(s): | Fig.2, 4, 8 |
| Annotation description: | Fig.8: "Neto1 and Neto2 increase GluK1 receptor surface trafficking and biophysical properties." - "In addition to measuring the size of the peak currents, we also measured the rate of deactivation and desensitization, parameters that might be affected by Neto proteins. Neto1 had no effect on the deactivation of GluK1-mediated currents, but Neto2 did slow deactivation (Figure 8D). By contrast, Neto1 enhanced the rate of desensitization, whereas Neto2 slowed the rate of desensitization (Figure 8E), in agreement with previous results (Copits et al., 2011)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3861 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |