| Annotated protein: | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK). Gene symbol: PTK2B. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9QVP9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTK2B |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Giralt A, et al. "Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model" Nat Commun. 2017 May 30;8:15592 PMID:28555636 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3: "Pyk2 localization and dendritic spine density and morphology in Pyk2-deficient mice" - "Pyk2 immunofluorescence in the neuropil was punctate and appeared to surround MAP2-positive dendritic processes (Fig. 3a). Some Pyk2-positive puncta co-localized with PSD-95-positive puncta, identifying them as PSDs (Fig. 3b)." - "We then examined Pyk2 immunoreactivity by electron microscopy. Pyk2-positive immunogold particles were found in both presynaptic elements and dendritic spines (Fig. 3c and Supplementary Fig. 3a). Pyk2 was enriched in asymmetric (presumably excitatory) synapses as compared to symmetric (presumably inhibitory) synapses (Supplementary Fig. 3a-d)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3855 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |