Annotated protein:	Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2). Gene symbol: PTK2B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P70600
antibody wiki:	search antibodypedia...
SynGO gene info:	SynGO data @ PTK2B
Ontology domain:	Biological Process
SynGO term:	postsynaptic modulation of chemical synaptic transmission (GO:0099170)
Synapse type(s):	Schaffer collateral synapse (CA3->CA1)
Annotated paper:	Bartos JA, et al. "Postsynaptic clustering and activation of Pyk2 by PSD-95" J Neurosci. 2010 Jan 13;30(2):449-63 PMID:20071509
Figure(s):	Fig.7
Annotation description:	[Fig.2: "Stimulation of Pyk2 binding to PSD-95 and Pyk2 autophosphorylation in intact neurons"] [Fig.3: "Ca2+/calmodulin stimulates PSD-95 binding to Pyk2"] [Fig.4: "Stimulation-induced synaptic clustering of Pyk2 in hippocampal neurons"] [Fig.5: "NMDA-induced Pyk2-GFP clustering occurs postsynaptically and independently of Pyk2 kinase activity"] [Fig.6: "Overexpression of the PSD-95 SH3 domain inhibits NMDA-induced Pyk2 clustering and Pyk2 autophosphorylation"] Fig.7: "Interfering with the PSD-95-Pyk2 interaction prevents induction of LTP"
Evidence tracking, Biological System:	Cultured neurons Non-neuronal tissue
Evidence tracking, Protein Targeting:	Over-expression Antibody (detection)
Evidence tracking, Experiment Assay:	Confocal IP + WB/MSMS
Annotator(s):	Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	3854
Dataset release (version):	20231201
View annotation as GO-CAM model: