| Annotated protein: | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK). Gene symbol: PTK2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P34152 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTK2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of modification of postsynaptic actin cytoskeleton (GO:1905274) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Shi Y, et al. "Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity" J Neurosci. 2009 Jun 24;29(25):8129-42 PMID:19553453 |
| Figure(s): | Fig.1, 2, 3, 6 |
| Annotation description: | Fig.1: "Disruption of FAK expression in 14 DIV hippocampal neurons promotes formation of new dendritic protrusions and elongation of existing ones" Fig.2: "FAK depletion affects dendritic spine morphology and synapses" Fig.3: "FAK depletion induces actin reorganization in 14 DIV hippocampal neurons." Fig.6: "Constitutively active FAK Y397E restores mature dendritic spine morphology disrupted by the inhibition of EphB2 receptor activity" 6/7/2018 Pim - The function of PTK2, FAK, FAK1 on spine morphology is shown to be mediated by cofilin, a protein that is known for its role in 'modification of postsynaptic actin cytoskeleton (GO:0098885)'. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | See also.... @ PMID:16298995 |
| SynGO annotation ID: | 3850 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |