| Annotated protein: | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK). Gene symbol: PTK2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35346 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTK2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Heintz TG, et al. "Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins" PLoS One. 2016 Aug 12;11(8):e0158558 PMID:27518800 |
| Figure(s): | Fig.2, 3, 4 |
| Annotation description: | Fig.2: "Manganese increases the number and the intensity of pFAK+ spines." Fig.3: "Effects of integrin manipulations on spine morphology, pFAK staining intensity and percentage of stained spines." Fig.4: " - "We applied the RGD peptide for one hour in Purkinje cell culture and measured the length of dendritic spines and pFAK on both proximal and distal dendrites. Both the intensity of pFAK staining and the number of pFAK+ spines were decreased after RGD treatment (p = 0.02, n = 12 and p = 0.04, n = 12 cells) confirming the ability of this peptide to decrease integrin signalling (Fig 3A, 3E and 3F), " |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3847 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |