| Annotated protein: | Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I). Gene symbol: HIP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8VD75 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HIP1 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Parker JA, et al. "Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity" J Neurosci. 2007 Oct 10;27(41):11056-64 PMID:17928447 |
| Figure(s): | Fig.4, 5 |
| Annotation description: | Fig.4: "Recovery from synaptic depression is delayed in slices from HIP1-/- mice" - "To determine whether recovery from synaptic depression is altered in HIP1-/- mice, a prolonged stimulation paradigm (10 Hz; 200 s) was applied to deplete the releasable synaptic vesicle pool, and subsequent recovery was monitored by stimulating at a lower frequency (0.33 Hz) (Fig. 4)...The expanded time base in Figure 4B shows that there was a trend toward a larger initial potentiation during the first 4 s of the tetanus in HIP1-/- mice compared with controls (p > 0.06). In addition, the rate of recovery from synaptic depression was significantly impaired in HIP1-/- mice (Fig. 4C)" Fig.5: "Short-term plasticity is enhanced in HIP1-/- mice" - " We first studied paired-pulse facilitation (PPF), in which delivery of two stimuli within a second of each other produces an increase in the size of the second synaptic response (Magelby, 1987). This increase in neurotransmitter release is thought to result from residual presynaptic Ca2+ that is still present after the first impulse, thereby increasing the probability of neurotransmitter release after invasion of the second action potential (Wu and Saggau, 1994; Kamiya and Ozawa, 1998)...A significant increase in PPF at interpulse intervals between 60 and 600 ms is evident in HIP1-/- mice compared with wild-type littermates (Fig. 6B) (t test, *p < 0.04)" 2/7/2018 Pim - I was not confident enough to make the annotation to term 'regulation of SV endocytosis' or 'regulation of SV cycle" based on this data. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3838 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |