| Annotated protein: | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1). Gene symbol: ARHGEF2. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: F7BYT9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARHGEF2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Muly EC, et al. "Subcellular distribution of the Rho-GEF Lfc in primate prefrontal cortex: effect of neuronal activation" J Comp Neurol. 2008 Jun 20;508(6):927-39 PMID:18399541 |
| Figure(s): | Fig.4, 5, 6, 9 |
| Annotation description: | - "We found that while Lfc was concentrated in dendrites, it also had a complex distribution in the neuropil, including being present in spines, axons, terminals and glial processes. Moreover, Lfc distribution varied in different layers of cortex. Using an in vitro slice preparation of monkey prefrontal cortex, we demonstrated an activity dependent translocation of Lfc from dendritic shafts to spines. " |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3837 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |