| Annotated protein: | Oligophrenin-1. Gene symbol: OPHN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0CAX5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ OPHN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Govek EE, et al. "The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis" Nat Neurosci. 2004 Apr;7(4):364-72 PMID:15034583 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "Distribution and localization of oligophrenin-1 in the brain" - "Our studies also showed that oligophrenin-1 is present at presynaptic sites. Endogenous oligophrenin-1 immunolabeling was observed as numerous puncta along axons and overlapped with synaptophysin at some presynaptic terminals (Fig. 1e). " |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3825 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |