| Annotated protein: | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11). Gene symbol: PRKACA. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P27791 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRKACA |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Perkins GA, et al. "PKA, PKC, and AKAP localization in and around the neuromuscular junction" BMC Neurosci. 2001;2:17 PMID:11716788 |
| Figure(s): | Fig.2 |
| Annotation description: | "We found partial overlap of the RIα label with synaptophysin, which labels presynaptic vesicles (fig. (fig.2a).2a). Importantly, RIα was observed to be concentrated in other vicinities of the presynapse as well. In the postsynaptic region, RIα immunoreactivity showed partial overlap with the mitochondrial marker (lipoic acid); overlap with mitochondria in muscle fibers was also observed (fig. (fig.2b).2b). In muscle, labeling of the I-band by anti RIα was dominant. The I-band contains actin and is where mitochondria are located, but has no myosin." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3822 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |