| Annotated protein: | Insulin-like growth factor I (IGF-I) (Somatomedin). Gene symbol: IGF1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P05017 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IGF1 |
| Ontology domain: | Cellular Component |
| SynGO term: | neuronal dense core vesicle lumen (GO:0099013) |
| Synapse type(s): | olfactory bulb, glutamatergic |
| Annotated paper: | Liu Z, et al. "IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning" Neuron. 2017 Jul 5;95(1):106-122.e5 PMID:28683263 |
| Figure(s): | Fig.5, 6 |
| Annotation description: | [Figure 4. Syt10 Is Essential for STFP-Induced LTP of G-M Synapses] Figure 5. IGF1 Induces Rapid Postsynaptic Potentiation of G-M Synapses Requiring IGF1-R Signaling Figure 6. IGF1-R Signaling Is Required by STFP-Induced LTP of G-M Synapses Discussion: "Odor exposure in a social context during STFP induces sustained Ca2+ entry in mitral cell dendrites and triggers both glutamate release and IGF1 exocytosis. IGF1 acts on IGF1-R and potentiates G-M synaptic strength by recruiting more GABA-R, which may be a synaptic substrate for the association of odor signals and social context." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3821 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |