| Annotated protein: | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]. Gene symbol: IGF1R. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q60751 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IGF1R |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | olfactory bulb, glutamatergic |
| Annotated paper: | Liu Z, et al. "IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning" Neuron. 2017 Jul 5;95(1):106-122.e5 PMID:28683263 |
| Figure(s): | Fig.5 |
| Annotation description: | [Figure 4. Syt10 Is Essential for STFP-Induced LTP of G-M Synapses] Figure 5. "IGF1 Induces Rapid Postsynaptic Potentiation of G-M Synapses Requiring IGF1-R Signaling" - "The IGF1-induced potentiation of G-M IPSCs was blocked by the IGF1 receptor (IGF1-R) antagonist NVP-AEW541 (Figures 5D-5F), indicating that the synaptic potentiation was specifically caused by IGF1." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3820 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |