| Annotated protein: | Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]. Gene symbol: NRG1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6DR98 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRG1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | spinal cord |
| Annotated paper: | Gallart-Palau X, et al. "Neuregulin-1 is concentrated in the postsynaptic subsurface cistern of C-bouton inputs to alpha-motoneurons and altered during motoneuron diseases" FASEB J. 2014 Aug;28(8):3618-32 PMID:24803543 |
| Figure(s): | Fig.1, 4 |
| Annotation description: | Fig.1: "NRG1 and its receptors ErbB2 and ErbB4 are associated with cholinergic C-bouton afferents on ventral horn MNs." Fig.4: "Ultrastructural immunolocalization of NRG1 at C-type synapses on spinal cord MNs" - "All procedures gave the same result, showing an exquisite localization of NRG1 within the postsynaptic subsurface cistern in association with MN C termini (Fig. 4A-E). " |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3813 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |