| Annotated protein: | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]. Gene symbol: ERBB4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61527 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ERBB4 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | spinal cord |
| Annotated paper: | Gallart-Palau X, et al. "Neuregulin-1 is concentrated in the postsynaptic subsurface cistern of C-bouton inputs to alpha-motoneurons and altered during motoneuron diseases" FASEB J. 2014 Aug;28(8):3618-32 PMID:24803543 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "phosphorylated ErbB2 (green; K) and ErbB4 (green; N) are present in VAChT-labeled C boutons (red; L, O); " - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. - The localization to the plasma membrane was inferred from the presumed role of Erbb4 as postsynaptic receptor for Neuregulin-1. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3812 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |