| Annotated protein: | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha). Gene symbol: PAFAH1B1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63005 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PAFAH1B1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Sudarov A, et al. "Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour" EMBO Mol Med. 2013 Apr;5(4):591-607 PMID:23483716 |
| Figure(s): | Figure 1, 2, 4 |
| Annotation description: | Fig.1: "In vivo two photon time lapse imaging in adolescent and young adult Lis1+/+ and Lis1+/- mice." - "Significant decreases occurred in turnover and elimination rates of filopodia in Lis1+/- animals over 10 min (Fig 1A and B, Supporting Information Fig 1A). " Fig.2: "Downregulation of RhoA in Lis1+/- neurons rescues motility in a subset of filopodia." Fig.4: "Reduced spine density in young pyramidal neurons of Lis1+/- mice." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Two-photon microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3809 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |