| Annotated protein: | Integrin alpha-3 (CD49 antigen-like family member C) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]. Gene symbol: ITGA3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q62470 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ITGA3 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Ross JA, et al. "Multiple roles of integrin-alpha3 at the neuromuscular junction" J Cell Sci. 2017 May 15;130(10):1772-1784 PMID:28386022 |
| Figure(s): | Fig.2, 3, 6, 7 |
| Annotation description: | Fig.2: "Altered localisation of AZ proteins and in the organisation of basal lamina at integrin-α3-mutant NMJs during early development." Fig.3: "Aberrant localisation of AZ proteins in NMJs of adult integrin-α3+/- mice" Fig.6: "Synaptic degeneration and upregulated autophagy in NMJs of adult integrin-α3+/- mice" Fig.7: "Nerve terminal detachment in integrin-α3+/- NMJs" - "Integrin-α3 is required for the connection of motoneurons to the muscle fibre" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | In the CNS Integrin alpha3 also has a role in synapse organization. @ PMID:23595732 |
| SynGO annotation ID: | 3805 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |