| Annotated protein: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2). Gene symbol: HCN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88704 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HCN1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane potential (GO:0060078) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Tsay D, et al. "HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons" Neuron. 2007 Dec 20;56(6):1076-89 PMID:18093528 |
| Figure(s): | Fig.2, 3, 5, 6, 8 |
| Annotation description: | Fig.2: "HCN1 Deletion Increases Magnitude and Prolongs Duration of Distal Ca2+ Events" Fig.3: "Pharmacological Blockade of Ih with ZD7288 Increases Amplitude and Duration of Distal Ca2+ Events" Fig.5: "Acute Blockade of Ih Prolongs Duration of the Long-Lasting Dendritic Depolarization in Response to PP but Not SC Stimulation" Fig.6: "Ca2+ Signals in Distal Dendrites Are Initiated by Activation of NMDA and AMPA Receptors, and Mediated by Ni2+-Insensitive T-Type and N-Type Voltage-Gated Ca2+ Channels" Fig.8: "Coapplication of ZD7288 with Elevated KCl Prevents the Hyperpolarization Induced by Ih Blockade and Inhibits Ca2+ Spike Enhancement" Note: the involvement of HCN1 in regulation of NMDA and AMPAR currents places the function of HCN1 in the synaptic scope. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Optical physiology |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3801 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |