| Annotated protein: | Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (mCPEB-2). Gene symbol: CPEB2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q812E0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CPEB2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of translation at synapse, modulating synaptic transmission (GO:0099547) |
| Synapse type(s): | brain, glutamatergic hippocampus, glutamatergic |
| Annotated paper: | Lu WH, et al. "CPEB2 Activates GRASP1 mRNA Translation and Promotes AMPA Receptor Surface Expression, Long-Term Potentiation, and Memory" Cell Rep. 2017 Nov 14;21(7):1783-1794 PMID:29141213 |
| Figure(s): | Fig. 6c |
| Annotation description: | CPEB2 activates GRASP1 mRNA Translation Contributing to AMPAR Recycling at synapse Furthermore in figure 5b immunohistochemistry on CPEB2 KO neurons shows less AMPAR at synapses |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Electrophysiology (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 3798 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |