| Annotated protein: | Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2). Gene symbol: KCNN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P58390 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNN2 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Sun J, et al. "UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis" Cell Rep. 2015 Jul 21;12(3):449-61 PMID:26166566 |
| Figure(s): | Figure 5 |
| Annotation description: | Figure 5: Reversal of LTP impairment in Ube3A null (AS) mice by apamin, an SK2 channel blocker shows that Ube3A depletion leads to higher membrane expression of SK2 leading to LTP impairments. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3793 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |