| Annotated protein: | Synaptotagmin-11 (Synaptotagmin XI) (SytXI). Gene symbol: SYT11. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9R0N3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYT11 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle endocytosis (GO:1900242) |
| Synapse type(s): | midbrain, dopaminergic |
| Annotated paper: | Wang C, et al. "Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology" Nat Commun. 2018 Jan 8;9(1):81 PMID:29311685 |
| Figure(s): | Fig.4, 5 |
| Annotation description: | Fig.4: "Syt11 inhibits endocytosis in neurons" - "we next determined whether the impaired DA transmission was also due to the inhibitory role of Syt11 in endocytosis in dopaminergic neurons...Furthermore, we used live imaging of the synaptophysin-pHluorin reporter, an assay for stimulated synaptic endocytosis/exocytosis (Fig. 4c), to monitor the function of Syt11 in endocytosis and vesicle recycling...we found a reduced paired-pulse ratio of DA release in ipsilateral striatal slices overexpressing Syt11" Fig.5: "Syt11 inhibits vesicle pool replenishment in dopaminergic neurons" - "we found a reduced paired-pulse ratio of DA release in ipsilateral striatal slices overexpressing Syt11" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Optical physiology Voltammetry assay |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3785 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |