| Annotated protein: | Syntaxin-4. Gene symbol: STX4. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70452 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STX4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Bin NR, et al. "Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons" Cell Rep. 2018 Jun 5;23(10):2955-2966 PMID:29874582 |
| Figure(s): | Figures 3-5 |
| Annotation description: | Figure 3. Tissue-Specific Syntaxin 4 Deletion Causes a Decrease in Both AMPAR- and NMDAR-Mediated fEPSPs as assessed in dendritic fEPSP recordings from CA1 neurons of control and syntaxin 4 cKO mice. Figure 4. Amplitude, but Not Frequency, of Spontaneous EPSCs of CA1 Pyramidal Neurons Is Reduced upon Syntaxin 4 cKO. Figure 5. Loss of Syntaxin 4 Leads to Reduced Surface Expression of Glutamate Receptors in Cultured Hippocampal Neurons |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Field recordings |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3759 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |