Annotated protein:Syntaxin-1A (Neuron-specific antigen HPC-1) (Synaptotagmin-associated 35 kDa protein) (P35A). Gene symbol: STX1A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P32851
antibody wiki:
SynGO gene info:SynGO data @ STX1A
Ontology domain:Cellular Component
SynGO term:integral component of postsynaptic density membrane (GO:0099061)
Synapse type(s):Schaffer collateral synapse (CA3->CA1)
Annotated paper:Hussain S, et al. "SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus" Front Mol Neurosci. 2016 Feb 5;9:10 PMID:26903802
Figure(s):Figures 3 5 &6
Annotation description:Figures 3A,B,D,E: postsynaptic spines were also clearly labeled, with immunogold labeling showing a somewhat similar labeling pattern as in the presynaptic terminal. Gold particles were noticably associated with the PSD (Figures 3D,F), but many postsynaptic vesicles were also immunopositive (Figures 3A,B). Some gold particles were also located along the pre- and postsynaptic lateral membranes. In dendrites, gold particles were associated with cytoplasmic vesicles along microtubules and attached to the DM (Figure 3C).
Figure 5 shows quantification of immune-gold particles at postsynapse.
Figure 6 shows postsynaptic colocalization with NMDA and AMPA receptors.

19/6/2018 Pim
- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Ruud Toonen (ORCID:0000-0002-9900-4233)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:3750
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology