| Annotated protein: | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1) (SH3 domain-containing protein 9). Gene symbol: BIN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O08539 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ BIN1 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle endocytosis (GO:0048488) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Di Paolo G, et al. "Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice" Neuron. 2002 Feb 28;33(5):789-804 PMID:11879655 |
| Figure(s): | Fig. 4,5,6 |
| Annotation description: | Synaptosomes of Amphiphysin knockout mice display reduced recycling of synaptic vesicles (Fig. 4 C,D). Cortical neurons in culture show also defects in synaptic vesicle dynamics as revealed by FM1-43 dye studies. 13/10/2017 Pim - Endocytosis of SVs is measured by quanitfying uptake of FM1-43 upon stimulation of synaptosomes. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Optical physiology |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 3746 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |