| Annotated protein: | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 2). Gene symbol: RIMS2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9EQZ7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RIMS2 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle priming (GO:0016082) |
| Synapse type(s): | hippocampus, glutamatergic hippocampus, GABAergic |
| Annotated paper: | Deng L, et al. "RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13" Neuron. 2011 Jan 27;69(2):317-31 PMID:21262469 |
| Figure(s): | fig 1C, 3E, 4, 5, 6 |
| Annotation description: | RIM1/RIM2 double knockout cultures have a reduction in the size of the sucrose pool at inhibitory synapses, demonstrating a role for RIM proteins in vesicle priming (fig 1c). This is mediated by activation of Munc13 through the Zinc finger domain (figures 3,4 5 and 6). Due to the strong homology between RIM1 and RIM2, both proteins are assumed to be redundant in this process. Action potential mediated pool measurements have confirmed a role in priming at the calyx of Held (Han et.al. 2011), and sucrose pool measurements in cultured neurons have confirmed this role at excitatory synapses (Kaeser et.al. 2011). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | sucrose pool measurements in cultured neurons have confirmed this role at excitatory synapses (Kaeser et.al. 2011). @ PMID:21241895 Action potential mediated pool measurements have confirmed a role in priming at the calyx of Held (Han et.al. 2011) @ PMID:21262468 |
| SynGO annotation ID: | 3736 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |