| Annotated protein: | Dedicator of cytokinesis protein 7 (Protein moonlight). Gene symbol: DOCK7. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R1A4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DOCK7 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic specialization assembly (GO:0098698) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Hallock PT, et al. "Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L" Genes Dev. 2010 Nov 1;24(21):2451-61 PMID:21041412 |
| Figure(s): | Fig.3 |
| Annotation description: | Crk-L is a postsynaptic protein which plays a crucial role in NMJ synapse formation concomitantly with CrkI/II, by directly interacting with Dok-7. Fig.3: "Dok-7 tyrosine phosphorylation plays a critical role in AChR clustering" - "(A,B) Overexpression of wild-type Dok-7 stimulated AChR clustering (~50-fold), independently of Agrin. Mutation of either Y396 or Y406 impaired AChR clustering, and mutation of both residues reduced AChR clustering still further" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 3730 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |